Transforming clinical research through innovation
At ICON, we’re not just leveraging technology, we're defining the possibilities from early phase through to post-marketing.
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ICON’s technology solutions are focused on the factors most critical to our customers. With expertise in technology harmonisation and systems integration, our innovative tools and platforms can be adopted smoothly, to enhance collaboration, increase transparency and drive productivity gains.
Accelerated Clinical Trials
FIRECREST
FIRECREST, ICON’s site portal, simplifies and streamlines the delivery of studies for sites and study teams. It is the industry’s largest site portal with over 500,000 site users in 143 countries. FIRECREST has been deployed on over 2,000 studies by 300+ Sponsors, including 18 of the top 20 pharmaceutical companies. Notably, it has a footprint of over 31,000 sites globally. This means that while your study may be new to sites, the same is very unlikely to be true of FIRECREST.
ICON Digital Platform
The ICON Digital Platform is an end-to-end solution to enable patient services throughout the clinical trial. Its ease of use supports patient centricity and reduces the barriers to trial participation thus enhancing equity, diversity and inclusion.
It has the technical functionality, standard capability, integrated services and the flexibility for any study design or therapeutic area (traditional to fully decentralised), in one platform, ensuring interoperability and harmonised data.
Artificial Intelligence
AI at ICON is leading the industry with multi award winning innovative and pragmatic solutions that are delivering measurable and impactful value to our clients.
One Search
Identify the right sites, the first time
One Search is ICON’s site selection system. It helps identify the right sites the first time.
One Search integrates and analyses billions of data points and trillions of data connections, and it uses human insight and artificial intelligence to identify the best sites based on ICON and industry knowledge of their experience and performance.
- 53% median time reduction to identify sites.
- Up to 50% reduction in the number of non-enrolling sites on ICON studies
- 24% improvement in customer satisfaction
Cassandra
Accurately predict postmarketing requirements as early as Phase 1
Cassandra harnesses real word data obtained from the postmarketing requirements (PMR) databases of the Food and Drug Administration (FDA) and European Medicines Agency (EMA) from 2003 forward. It applies AI and machine learning to the information to predict if and what types of postmarketing requirements will be required by the FDA and/or EMA on new products. Understanding additional requirements can be critical for the overall success of a new drug and managing the cost and risk involved.
- 99% and 97% accuracy predicting PMRs from the FDA and EMA, respectively
ICONex
Finding rare disease experts
Network graph that builds a comprehensive picture of expert publication, peer relationships and influence.
ICON consultants can quickly identify the best key opinion leaders and geographic locations for any rare disease opportunity.
- Quicker path to study design
- Identification of disease indication networks
- Key insights for feasibility plans
MRT COA
AI powered outcomes intelligence
Natural language processing and fine-tuned large language models auto-update our existing eCOA database and add new eCOAs to the repository based on published resources.
The ICON commercialisation and outcomes team, in association with ICON’s Mapi Research Trust, can recommend optimal outcomes strategies for protocol design and execution.
- Near real-time sync with published outcomes research
- Gather intelligence on outcomes trends and effectiveness
- Build new commercial opportunities in healthcare intelligence beyond clinical research
iSubmit
Auto-filing and improved compliance
Automation of simple but repetitive eTMF filing tasks, and complex determinations for eTMF document dependencies can be made through AI insight.
- Decreased burden on study teams
- Automated indexing and indexing QC
- Reduced audit findings because of AI coherence checks
- Expert hours repurposed for advanced coherence checks
Technology solutions
We develop integrated technologies to significantly enhance the efficiency and productivity of clients’ drug and device development programs, providing true transparency across all areas of a study.
Data analysis
- Control Tower Control Tower from ICON gives you powerful real-time data so you can monitor the progress of your trial, spot emerging trends, and identify outliers.
- ICONIK An informatics platform to analyse the operational, clinical and real world data collected during clinical development.
Control Tower
Control Tower from ICON gives you powerful real-time data so you can monitor the progress of your trial, spot emerging trends, and identify outliers.
ICONIK
An informatics platform to analyse the operational, clinical and real world data collected during clinical development.
Risk management & safety
- Signet Providing in depth insights on your patient safety data.
- NONMEM® ICON’s nonlinear mixed effects modelling tool, the industry standard for population PK/PD analysis.
- Safety Reporting Solution A cloud-based system featuring automated and configurable business rules to ensure regulatory compliance and provide visibility into the safety profile of an investigational product throughout its lifecycle.
- PDx-POP® PDx-POP is ICON’s software tool for expediting the iterative process of population pharmacokinetic modeling and analysis.
Signet
Providing in depth insights on your patient safety data.
NONMEM®
ICON’s nonlinear mixed effects modelling tool, the industry standard for population PK/PD analysis.
Safety Reporting Solution
A cloud-based system featuring automated and configurable business rules to ensure regulatory compliance and provide visibility into the safety profile of an investigational product throughout its lifecycle.
PDx-POP®
PDx-POP is ICON’s software tool for expediting the iterative process of population pharmacokinetic modeling and analysis.
Streamlined trials
- Flex Advantage™ Interactive Response Technology (IRT) platform for managing patient randomisation, investigator sites, and clinical supplies.
- Flex Advantage Express™ Flex Advantage Express is a configurable, web-based platform that provides an effective and efficient solution for managing patient data collection, enrolment, randomisation and drug supply/dosing regimens.
Flex Advantage™
Interactive Response Technology (IRT) platform for managing patient randomisation, investigator sites, and clinical supplies.
Flex Advantage Express™
Flex Advantage Express is a configurable, web-based platform that provides an effective and efficient solution for managing patient data collection, enrolment, randomisation and drug supply/dosing regimens.
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Prism Connect
Prism Connect extracts clinical trial information directly from a site’s electronic health records (EHR).
ICOMaster
ICOMaster is ICON’s electronic Trial Master File (eTMF) system. It offers clients secured access to files hosted on the platform.
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Symphony Health
Symphony Health has one of the largest integrated repositories of healthcare data for most of the US population i.e. 307 million patients.
Laboratories & Medical Imaging
- LabView360 Simplifying the real-time collection, registering and management of samples.
- ICOlabs ICOlabs is a remote data access tool that enables sponsors to designate study-specific key indicators and custom reports to track specific study trends.
- iSite ICON Central Laboratories’ secure portal that provides any-time access to site-specific information.
- iRIS iRIS (ICON Results Integration Services) enables the collection of synchronised data from local laboratories into one central database for streamlined analysis and expedited regulatory submission to meet the demands of today’s clinical trials.
- MIRA MIRA (Medical Image Review and Analysis), is an image data host and data management platform integrated with ICON’s global LIMS.
- SIMS Sample Inventory Management System (SIMS) is an interactive reporting module in ICOLabs offering near real-time, high level traceability of all patient samples in a clinical trial.
LabView360
Simplifying the real-time collection, registering and management of samples.
ICOlabs
ICOlabs is a remote data access tool that enables sponsors to designate study-specific key indicators and custom reports to track specific study trends.
iSite
ICON Central Laboratories’ secure portal that provides any-time access to site-specific information.
iRIS
iRIS (ICON Results Integration Services) enables the collection of synchronised data from local laboratories into one central database for streamlined analysis and expedited regulatory submission to meet the demands of today’s clinical trials.
MIRA
MIRA (Medical Image Review and Analysis), is an image data host and data management platform integrated with ICON’s global LIMS.
SIMS
Sample Inventory Management System (SIMS) is an interactive reporting module in ICOLabs offering near real-time, high level traceability of all patient samples in a clinical trial.
Featured webinars
Artificial Intelligence at ICON
How are world leading healthcare intelligence CRO is transforming the delivery of clinical trials.
The future of pharmacovigilance: Exploring automation and AI in literature surveillance.
In this webinar, industry experts explore the future of Pharmacovigilance and offer key insights on the critical role of literature surveillance in the pharmaceutical and biotech sectors, and how automation is revolutionising the process.
Featured whitepapers
Advancements in Artificial Intelligence for site selection
By harnessing the combined power of human expertise and AI technology, One Search delivers significant improvements across all key metrics, including recruitment rates, site identification speed, and compliance with project timelines.
Beyond the token: Why real-world healthcare data and integration strategy matters
This whitepaper explores the challenges and opportunities arising from the proliferation of healthcare data, emphasising the need for robust data integration strategies to leverage this data effectively.
Applying AI to manage the risks and costs of postmarketing requirements
Our Cassandra AI system harnesses RWD on drugs and data obtained from the US FDA and EMA postmarketing requirements databases to accurately forecast whether postmarketing studies will be necessary.