Central Nervous System
Insights on the major trends in aging disorders and pain conditions including the development of targeted therapies in clinical trial designs and patient care.
Expert opinions on innovative processes include protocol design, site training, and real time data quality analysis in central nervous systems.
Clinical strategies to optimise software as a medical device (SaMD) for treating mental health
Mental health disorders affect millions, and with increasing diagnoses, the demand for new, accessible treatments is growing. In this whitepaper, we examine how SaMD, particularly through digital therapeutics, is providing new solutions for mental health management.
Therapeutic spotlight: Precision medicine considerations in rare diseases
In our latest therapeutic spotlight, ICON’s experts explore the evolving therapeutic landscape of precision medicine with a special focus on the unique application in ALS. We outline key considerations for developing patient-centric, streamlined precision medicine programs that promote patient engagement, improve protocol adherence and reduce dropout rates – ultimately accelerating the delivery of meaningful therapies to patients.
A mind for digital therapeutics: Considerations for DTx clinical trials in CNS indications
DTx deliver evidence-based therapeutic intervention using software to prevent, manage, or treat medical disorders or disease. Because of the evidence-based nature of DTx, in many cases a clinical trial is required to demonstrate safety and efficacy. However, since such therapeutics are relatively new, there are many aspects to these clinical trials that differ from trials for traditional therapeutics, and which sponsors will need to consider.
Traumatic brain injury trials
The manifestations and effects of TBI are varied and impact diverse populations. To improve prevention and therapy, we need to conduct further clinical research to evaluate and validate better strategies for diagnosis and disease characterisation. A better understanding of how TBI — mild and severe — manifests, can lead to better identification of biomarkers, and the development of prevention and treatment strategies.
Key considerations for Parkinson’s disease trials
While there are many advances in Parkinson’s Disease (PD), such as identification of new biomarkers to measure disease progression, valuable insights in study design coming from Alzheimer’s Disease trials, and creative approaches for patient recruitment, challenges still remain in this therapeutic area.
Key considerations in chronic pain clinical trials
There has been an increased prevalence of lifetime substance abuse, creating an urgent need for innovative pain medications without the use of opioids. Unfortunately, clinical development of non-opioid pain medications has been hindered by a massive placebo-response.In our whitepaper, we discuss the aspects of pain studies that sponsors will need to consider to ensure success of their chronic pain trial model.
Autism Spectrum Disorders: Approved therapies and clinical trials
The prevalence of Autism Spectrum Disorders is increasing over time due to changes in the definition of the disorder and earlier and better detection. In this podcast, ICON experts share an overview of Autism Spectrum Disorder, the pathogenesis and the challenges and future direction of clinical trials.
Blogs and media articles insights in central nervous system and Alzheimer's disease
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Blog: The role of technology in Parkinson’s treatment and research
Constant study and innovation of Parkinson's Disease (PD) research has shown the implementation of medical devices, AI, and mobile applications pave the way forward.
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Media article: Engaging the crowds
Patient registries need to be offering more support and convenience to ensure greater engagement and enrolment in clinical trials.
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Media article: Alzheimer’s in Clinical Trials – Is There a Way Out of Ongoing Failures?
The attempt to develop a causal treatment against the progression of Alzheimer’s disease is an unparalleled series of nearly two decades of failures in drug development.
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Blog: Key Considerations for Disease-Modifying Parkinson’s Disease Trials
Taking into consideration the lessons learned from Alzheimer’s disease studies could benefit the design of neuro-protective studies.
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Media article: Shock to the System: An Examination of Neurostim Technologies
Learn how targeted electrical nerve stimulation technology can aid in chronic disease management by improving on current treatment methods in MPO Magazine's recent article.
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Blog: Alzheimer’s in Clinical Trials
Attempting to develop casual treatment against the progression of Alzheimer’s disease has resulted in unparalleled series of failures for nearly 2 decades of drug development.
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Media article: Parkinson’s Disease Clinical Trials
An Outsourcing-Pharma article exploring Parkinson’s disease clinical trials, featuring commentary from ICON Central Nervous System (CNS) experts Dr Peter Schueler (Sr VP, Drug Development Services) and Haichen Yang (VP, Global Therapeutic Lead).
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Media article: Disruptive Innovation
A whitepaper by ICON on disruptive innovation in the life science industry, based on a panel session hosted by ICON early in 2018 to gather views from senior executives from leading pharma companies on disruptive innovation.
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CNS, Pain and Ageing related disorders
ICON’s experience of CNS, Pain and Ageing related disorder studies comprises global and regional clinical research in all major areas of neurology, psychiatry and pain research, and all phases of clinical drug development. Read more about ICON's services.